In the field of oral and maxillofacial tissue regeneration, growth modulators have attracted a great deal of attention. Platelet concentrates like platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) are rich in growth factors such as platelet derived growth factor, transforming growth factor- beta (TGF-β), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and cytokines which facilitate excellent and fast soft tissue healing.
The multilineage differentiation capacity, accessibility of cell collection, non-invasive separation technique, and quick in vitro extension makes stem cells a promising scaffold in the field of tissue regeneration. Mesenchymal stem cells (MSCs) help in bone regeneration owing to their unique properties of angiogenesis, anti-apoptosis and immunomodulation. Precisely planned scaffolds may promote the oral and maxillofacial tissue renewal. When these scaffolds are used with stem cells and bioactive factors like bone morphogenetic proteins (BMPs) and stromal cell derived factor 1 (SDF1), they help to re-establish the lost