Certain OPMDs, such as oral submucous fibrosis, are encountered particularly with specific lifestyle habits. The main objective is secondary prevention by early detection of PMDs when they can be treated most effectively. PMDs are often undiagnosed due to lack of public awareness and due to lack of knowledge among medical professionals. Clinical appearance and diagnosis of a lesion is not adequate to determine its premalignant nature as not all white lesions turn malignant. Diagnostic biopsy and histopathological examination should be considered for any mucosal lesion that persists for more than 14 days after obvious irritants have been removed. Prognosis and patient survival is directly related to stage and grade of cancer at initial diagnosis. He has a keen interest in the management of Potentially Malignant Disorder