EFFECTIVENESS OF SELF ASSEMBLING PEPTIDE (P11-4) IN ENAMEL REMINERALIZATION

Self-assembling peptide P11-4 has garnered significant attention in the field of dentistry due to its remarkable effectiveness in promoting dental hard tissue regeneration. P11-4 is a synthetic biomaterial composed of short peptides that can spontaneously assemble into nanofibrous scaffolds, mimicking the extracellular matrix structure in teeth. This self-assembly property allows P11-4 to provide a supportive environment for dental tissue repair.

MODE OF ACTION

The ẞ-sheet-forming peptides, P11-4, that self-assemble themselves the to form three-dimensional scaffolds under defined environmental conditions have been shown to nucleate hydroxyapetite. The anionic groups of the P11-4 side chains attract Ca++ ions, inducing the precipitation of HAP in situ. Self-assembly of these structures can result in the formation of nanostructures, including nanofibers, nanotubes, and nanovesicles.

APPLICATIONS

Early enamel caries remineralization

 The peptide self-assembles into a viscous fibrous scaffold under the influence of the circumstances seen in a carious environment. The anionic groups in peptide P11-4 attract calcium ions and can precipitate hydroxyapatite crystals from scratch. The nucleator pulls ions out of tissue fluids and organises them into a crystalline structure.

Orthodontic treatment- induced caries

Demineralisation can occur near brackets during fixed orthodontic treatment. Early enamel alterations may progress, and WSLs may arise if appropriate preventative strategies are not used. . They came to the conclusion that the mineral gain effectiveness of fluoride varnish is superior to the one-time application of fluoride varnish. The benefit is that it improves enamel remineralisation, which is especially important in these patients because fluoride alone may not be enough. As a result, preparation of the enamel surface with P11-4 peptide prior to bracket insertion is a viable option.

Hypersensitivity of the dentin

Dentine hypersensitivity (DH) is widely believed to occur as a result of fluid flow within exposed dentinal tubules in the tooth surface. Most treatments are designed to occlude these tubules. Due to hydroxyapatite binding sites, the self-assembling peptide P11-4 has a high affinity for the dentinal surface. As a result, electrostatic interactions bind the matrix to the tooth, due to which the dentinal tubules are occluded, and dentinal hypersensitivity is reduced due to these interactions.